Small-molecule Library Screening
Qualified Assays of Screening
Protein-based biochemical assays (fluorescence- or luminescence-based assays)
These screens use purified proteins and substrates in buffered solutions to produce an optical (fluorescent, luminescent, etc.) readout that monitors enzymatic or binding activity. Small compound inhibitors are ranked by the signals, referring to targeted protein function, in this type of screen.
Cell-based assays (Luciferase-based signal detection or Image-based analysis)
These screens can be macromolecular or small-molecule screens that utilize cells plated in 96 or 384 or 1536 well plates to produce visual phenotypic or signal changes in the cells. The measurement can be a signal- or image-based readouts.
GRC collection for screening
Information associated with each compound in our database are molecular weights, logP values, sources of collection, and the LC‐MS analytic results.
Pilot (2K)
The test consists of ~2,000 FDA-approved drugs.
Probe Set (9K)
It consists of FDA-approved drugs and randomized compounds with annotated activities. The library has 25% overlapping.
Library 1 (25 K)
The library contains annotated compounds, including FDA-approved drugs, natural product derivatives, compounds with known activities, and traditional Chinese medicine.
Library 2 (40 K)
The library consists of Library 1 (25 K) and Discovery Diversity Set (Enamine, 20K)
Library 3 (120 K)
The library consists of Library 1 (25 K), Discovery Diversity Set (Enamine, 60K), and representative compounds from GRC 2M library
Customized library
Cannot find the library of interest? Create your own library from GRC collection!