Core Technology & Facilities

The goal of assay development focuses on miniaturizing the assays for 384- and 1536-well plates and on the delivery of robust and well validated assays for HTS.

The ultra high-throughput screening (uHTS) system at GRC has unsurpassed screening capacity,  accuracy, and flexibility.

Current library contains mostly small molecular compounds with drug‐like properties followed an extended Lipinski’s rules of five (RO5). The collected compounds were reformatted into wells of 384- and 1536-well plates and stored at 1 mM in 100% DMSO.

Spebox allows high-throughput screening of mixtures into a maximum of 352 tubes

The fluorescence or luminescence signal of a plate is read by the ViewLux imager and PHERAStar plate reader. 

Versatile liquid handling systems fulfill the needs of transferring liquids between tubes, 96-, 384-, and 1536-well plates